The Californian city's two biggest hotels, the Hilton Parc 55 and Hilton San Francisco Union Square, have lost a combined $1billion in value, according to the Kroll Bond Rating Agency.
Their worth is now $553.8 million.
Meanwhile, the delinquency rate among commercial mortgage-backed security loans for the sector jumped to 41.6 percent in June from 5.7 percent the same time last year, according to data from real estate analytics firm Trepp.
It comes as San Francisco's tourism industry struggles to recover to its pre-pandemic levels, while other parts of the country bounce back.
Anna Marie Presutti, interim president of the San Francisco Travel Association, told The Wall Street Journal that 2024 'is definitely a difficult year'.
She said she did not expect visitor numbers to recover until 2028 or 2029.
Weekend hotel occupancy in June, a rough gauge for leisure travel, is down 22 percent since 2019 in the San Francisco-San Mateo region, compared to four percent nationwide, according to data firm CoStar Group.
The Journal suggested that tourists were being put off by 'quality-of-life issues'. Cost of living in San Francisco is notoriously high - with the Bay Area being the second-richest area in the US, behind New York City.
Open air drug markets, a growing homeless population, and increased crime has left many San Francisco neighborhoods in turmoil.
Compounding the issue is a strong dollar, which is encouraging more Americans to travel abroad.
Meanwhile, Chinese tourists, a major source of visitors, are deterred by the strong dollar and economic uncertainty.
Travel for work has also recovered since the pandemic, replacing the need for some to pay for expensive trips, according to CoStar.
Hospitality workers are now feeling the pinch, with a reduction in hours forcing many to take on second jobs.
Contracts covering the Bay Area's roughly 10,000 hotel workers expire this month, and 3,000 employees overwhelmingly voted to authorize a potential strike, their union announced.
Hannah Lin, a room attendant at the Union Square Hilton, said she had taken up a second job at the Oracle Ballpark after her hours were cut dramatically.
Real-estate investment trust Park Hotels & Resorts has now dropped Hilton Parc 55 and its Union Square hotel from its portfolio.
Tom Baltimore, the firm's chief executive, said during a first-quarter earnings call that doing so 'meaningfully improved our balance sheet and operating metrics', the WSJ reported.
